Kidney Disease Research Updates
Winter 2007

Resources

Featured in the NIDDK Reference Collection

Anemia and Diabetic Nephropathy

The prevalence of anemia in people with diabetes is twice that seen in people with nondiabetic renal disease and similar kidney function. This chapter on anemia and diabetic nephropathy is from a clinical textbook, The Diabetic Kidney. The authors address the epidemiology and possible mechanisms associated with anemia in the setting of diabetic nephropathy. They describe the prevalence of anemia in three Australian clinics and compare this with large, community-based studies of anemia, including the Third National Health and Nutrition Examination Survey (NHANES III). The role of functional erythropoietin deficiency is also discussed.

In the second part of the chapter, the authors consider anemia associated with advanced diabetic nephropathy, including the emerging concept that anemia is not only a product of the renal impairment process but also a contributor to congestive heart failure development and increased cardiovascular mortality associated with end-stage renal disease in people with diabetes.

The final section examines the potential role of iron and erythropoietin in treating anemia in patients with diabetes and the difficulties in interpreting the cardiovascular and renal outcomes of intervention studies. The chapter begins with a topics outline and ends with an extensive list of 76 references. This book is available for $175 from Humana Press, www.humanapress.com, at 999 Riverview Drive, Suite 208, Totowa, NJ 07512, or humana@humanapr.com. Visit the Reference Collection at www.catalog.niddk.nih.gov/resources to find more resources on kidney disease.

NIH Publication No. 07–4531
March 2007

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